Lesson Plan

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Lesson Plan
Grade: A-Level Date: 17/01/2026
Subject: Biology
Lesson Topic: relate the structures of collagen molecules and collagen fibres to their function
Learning Objective/s:
  • Describe the Gly‑X‑Y repeat in collagen’s primary structure and its role in forming the triple helix.
  • Explain how the triple‑helix architecture enables fibril assembly and provides tensile strength.
  • Analyse the relationship between each hierarchical level of collagen and its mechanical function in connective tissues.
  • Evaluate clinical conditions (e.g., scurvy, osteogenesis imperfecta) that illustrate structure‑function links.
Materials Needed:
  • Projector and screen for slides/diagrams
  • Whiteboard and markers
  • Handout summarising collagen hierarchy and key features
  • 3D model or printed diagram of a collagen fibre
  • Worksheets with case‑study questions on clinical relevance
  • Sticky notes or index cards for quick‑fire quiz
 Introduction:
Begin with a striking image of a torn tendon and ask students why some tissues can withstand great tension while others cannot. Recall that proteins provide structural support and that collagen is the most abundant protein in mammals. Today we will explore how collagen’s molecular architecture underpins its mechanical function, and we will check our understanding through a brief exit ticket.
Lesson Structure:
  1. Do‑now (5'): Students label a blank diagram of the collagen hierarchy on a handout.
  2. Mini‑lecture (10'): Present primary structure and triple‑helix formation using projector and 3D model.
  3. Guided inquiry (12'): In pairs, analyse a table linking structural levels to functional properties; fill in missing entries.
  4. Demonstration (8'): Show a short video of tendon stretching; discuss how fibril cross‑links contribute to tensile strength.
  5. Clinical case discussion (10'): Groups evaluate scurvy vs. osteogenesis imperfecta, linking genetic/nutritional defects to structural changes.
  6. Check for understanding (5'): Quick quiz via Kahoot or sticky‑note responses.
  7. Summary & transition (5'): Teacher recaps key points and previews the next topic on extracellular matrix proteins.
Conclusion:
Summarise how each hierarchical level of collagen builds upon the previous to give tissues their strength and flexibility. Students complete an exit ticket describing one way a structural defect can affect function. For homework, assign a short research task on a collagen‑related disease and ask students to prepare a one‑page summary.