Lesson Plan

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Lesson Plan
Grade: Date: 25/02/2026
Subject: Biology
Lesson Topic: relate the structure of haemoglobin to its function, including the importance of iron in the haem group
Learning Objective/s:
  • Describe the quaternary structure of haemoglobin and its subunit composition.
  • Explain how the iron atom in the haem group binds oxygen and why Fe²⁺ is essential.
  • Analyze how conformational changes (T to R) lead to cooperative oxygen binding.
  • Evaluate the impact of allosteric effectors (2,3‑BPG, pH, CO₂) on haemoglobin function.
  • Apply knowledge of haemoglobin structure to explain clinical conditions such as iron‑deficiency anaemia and carbon monoxide poisoning.
Materials Needed:
  • Projector or interactive whiteboard
  • PowerPoint slides with haemoglobin diagrams
  • Haemoglobin model kits (optional)
  • Handout summarising structure–function points
  • Whiteboard and markers
  • Exit‑ticket slips
 Introduction:
Begin with a quick poll: “What gives blood its red colour?” Connect responses to the presence of iron in haemoglobin. Review prior learning on protein structure and state that by the end of the lesson students will be able to link haemoglobin’s structure to its oxygen‑transport function.
Lesson Structure:
  1. Do‑now (5') – Students answer the poll on sticky notes and share ideas.
  2. Mini‑lecture (10') – Present the quaternary structure, subunits, and haem group using slides.
  3. Interactive model activity (12') – In pairs, assemble a haemoglobin model kit, locate the iron atom, and label T/R states.
  4. Cooperative binding demonstration (8') – Use a simulation to illustrate the Hill equation and the T→R shift.
  5. Allosteric effectors discussion (7') – Small‑group analysis of 2,3‑BPG, the Bohr effect, and related clinical examples.
  6. Formative check (5') – Quick quiz (Kahoot or handout) covering key concepts.
  7. Summary & exit ticket (3') – Students write one structure‑function link on a slip for exit.
Conclusion:
Recap the essential link between haemoglobin’s quaternary structure, iron’s role, and cooperative oxygen binding. Students complete an exit ticket describing one way a structural change affects function. For homework, read a short case study on carbon monoxide poisoning and write a paragraph explaining the molecular basis of its effect.