Lesson Plan

Resources → Subject Notes → Biology → Notes
Lesson Plan
Grade: Date: 25/02/2026
Subject: Biology
Lesson Topic: explain that gene editing is a form of genetic engineering involving the insertion, deletion or replacement of DNA at specific sites in the genome
Learning Objective/s:
  • Describe the molecular steps of gene editing, including target recognition, DNA cleavage, and cellular repair pathways.
  • Explain how CRISPR‑Cas9, TALENs, and ZFNs enable insertion, deletion, or replacement of DNA sequences.
  • Compare the advantages of gene editing with conventional genetic engineering and discuss related ethical considerations.
Materials Needed:
  • Projector and screen for slide presentation
  • Printed handout summarising repair pathways (NHEJ & HDR)
  • Computers or tablets with internet access for an online CRISPR design simulation
  • DNA model kits or printable DNA strand cut‑outs for a hands‑on activity
  • Exit‑ticket slips or digital form
 Introduction:

Begin with a short video clip showing a real‑world application of gene editing (e.g., sickle‑cell therapy) to capture interest. Ask students what they already know about DNA manipulation and how it differs from older genetic modification methods. Explain that by the end of the lesson they will be able to trace the gene‑editing process and evaluate its benefits and risks.
Lesson Structure:
  1. Do‑Now (5'): Quick quiz on DNA structure and basic genetic engineering concepts.
  2. Mini‑lecture with slides (10'): Define gene editing, outline the four mechanistic steps, and introduce CRISPR‑Cas9, TALENs, and ZFNs.
  3. Interactive simulation (15'): Students use an online CRISPR design tool to create a guide RNA for a given target gene and predict repair outcomes.
  4. Group case‑study activity (10'): Analyze a point‑mutation correction scenario, identify which repair pathway (NHEJ vs. HDR) is involved, and discuss expected results.
  5. Ethics discussion (5'): Whole‑class brainstorm of potential societal and safety issues.
  6. Exit ticket (5'): Each student writes one key takeaway and one question they still have.
Conclusion:

Summarise how gene editing achieves precise DNA modifications and why repair pathway choice matters. Collect exit tickets to gauge understanding and assign a short homework: read a recent news article on a gene‑editing breakthrough and write a 150‑word reflection on its ethical implications.